Shopping Cart
- Remove All
Your shopping cart is currently empty
INCB3619
Catalog No. T27603Cas No. 791826-72-7
Alias INCB-3619, INCB 3619
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
INCB3619
Catalog No. T27603Alias INCB-3619, INCB 3619Cas No. 791826-72-7
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "INCB3619"
Benzyl cinnamate
Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate
T8145103-41-3
Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.
- $42
Size
QTY
Benzyl cinnamate
Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate
T8145103-41-3
Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.
- $42
Size
QTY
Benzyl cinnamate
Cinnamic acid benzyl ester, Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate
T8145103-41-3
Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.
- $42
Size
QTY
beta-Escin
B-escin, AESCINE
T884611072-93-8
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
- $50
Size
QTY
beta-Escin
B-escin, AESCINE
T884611072-93-8
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
- $50
Size
QTY
Anti-inflammatory agent 36
T643592293951-01-4
Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
- $43
Size
QTY
Anti-inflammatory agent 35
T643582293951-00-3
Anti-inflammatory agent 35 is a potent anti-inflammatory agent.
- $38
Size
QTY
Glimepiride sulfonamide
T64332119018-29-0
Glimepiride sulfonamide is an antiinflammatory agent.
- $31
Size
QTY
8-Epideoxyloganic acid
T383488668-99-9
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit
- $83
Size
QTY
8-Epideoxyloganic acid
T383488668-99-9
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit
- $83
Size
QTY
Select Batch
Purity:100%
ee:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15. |
| Targets&IC50 | Heregulin:0.24 μM |
| In vitro | The dual ADAM inhibitor INCB3619 inhibits heregulin cleavage with an IC50 value of 0.24 μM[1].Treating A549 cells in serum-free culture with varying concentrations of gefitinib and INCB3619 (2-10 µM) for 96 hours revealed that INCB3619 sensitizes A549 cells to gefitinib[1]. |
| In vivo | INCB3619 was administered subcutaneously using ALZET osmotic pumps at doses of 30 or 60 mg/kg/day for 14 days. The results showed that the ADAM inhibitor INCB3619 inhibited gefitinib-resistant HER3 autocrine mechanism, exerting antitumor activity in vivo, and sensitizing tumors to chemotherapy drugs[1]. |
| Alias | INCB-3619, INCB 3619 |
| Molecular Weight | 413.47 |
| Formula | C22H27N3O5 |
| Cas No. | 791826-72-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy INCB3619 | purchase INCB3619 | INCB3619 cost | order INCB3619 | INCB3619 chemical structure | INCB3619 in vivo | INCB3619 in vitro | INCB3619 formula | INCB3619 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.