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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $64 | In Stock | |
5 mg | $228 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $613 | In Stock | |
50 mg | $869 | In Stock |
Description | Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity. |
In vitro | Ac-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3]. |
In vivo | In SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4]. |
Alias | Caspase-1 Inhibitor II, Ac-Tyr-Val-Ala-Asp-chloromethylketone, Ac-Tyr-Val-Ala-Asp-CMK |
Molecular Weight | 540.99 |
Formula | C24H33ClN4O8 |
Cas No. | 178603-78-6 |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (166.4 mM), Sonication is recommended. DMF: 10 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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