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Letolizumab
🥰Excellent
Catalog No. T77061Cas No. 1450981-87-9
Alias BMS-986004, BMS986004, BMS2h-572-633-CT-L2
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
Letolizumab
Letolizumab
🥰Excellent
Catalog No. T77061Alias BMS-986004, BMS986004, BMS2h-572-633-CT-L2Cas No. 1450981-87-9
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $169 | In Stock | |
| 5 mg | $448 | In Stock | |
| 10 mg | $715 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,460 | In Stock |
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Concentration:7.21 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates. |
| Targets&IC50 | CHO-CD40L (non-human primate):7.3 nM, CHO-CD40L (human):1.3 nM, CD40L trimer (human):3.6 nM, CD40L trimer (non-human primate):3.8 nM |
| In vitro | Letolizumab inhibited the viability of CD40L trimer and CHO-CD40L in human B-cells and in non-human primate B-cells with IC50 values of 3.6 nM and 1.3 nM, and 3.8 nM and 7.3 nM, respectively. [2] |
| In vivo | Letolizumab treatment at doses of 2, 10, and 20 mg/kg administered intravenously once a week for 10 weeks significantly prolonged the survival time of rhesus monkeys after kidney transplantation. [2] |
| Alias | BMS-986004, BMS986004, BMS2h-572-633-CT-L2 |
| Cas No. | 1450981-87-9 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Related Tags: buy Letolizumab | purchase Letolizumab | Letolizumab cost | order Letolizumab | Letolizumab in vivo | Letolizumab in vitro
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