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ZIP acetate(863987-12-6 free base)

ZIP acetate(863987-12-6 free base)
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Catalog No. TP1924L1
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Purity:94.68%
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ZIP acetate(863987-12-6 free base)

Catalog No. TP1924L1

ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
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Pack SizePriceAvailabilityQuantity
1 mg$80In Stock
5 mg$181In Stock
10 mg$272In Stock
25 mg$448In Stock
50 mg$630In Stock
100 mg$852In Stock
200 mg$1,130In Stock
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Product Introduction

Bioactivity
Description
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-ph
Chemical Properties
Molecular Weight1988.43
FormulaC92H158N30O19
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Insoluble
H2O: 5 mM
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5029 mL2.5145 mL5.0291 mL25.1455 mL
5 mM0.1006 mL0.5029 mL1.0058 mL5.0291 mL

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