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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
2 mg | $143 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $327 | In Stock | |
25 mg | $552 | In Stock | |
50 mg | $793 | In Stock | |
100 mg | $1,090 | In Stock |
Description | PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC. |
In vitro | PKCε Inhibitor Peptide acetate(1 µM; 24 hours) significantly inhibits Oleic acid-induced connexin 43 Ser368 phosphorylation and prevents Oleic acid-induced gap junction disassembly in cardiomyocytes[1]. |
In vivo | In C57BL/6J mice transplanted the hearts of FVB mice, PKCε Inhibitor Peptide acetate (20 mg/kg/day; osmotic pumps s.c.) significantly improved the beating score throughout the treatment. PKCε Inhibitor Peptide acetate treatment almost abolished the rise in pro-fibrotic cytokine, TGF-β, and monocyte recruiting chemokine MCP-1 levels. PKCε Inhibitor Peptide acetate reduced the infiltration of macrophages and T cells into the cardiac grafts and decreased parenchymal fibrosis[2]. |
Alias | PKCε Inhibitor Peptide acetate(182683-50-7 Free base) |
Molecular Weight | 904.02 |
Formula | C39H69N9O15 |
Cas No. |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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