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PKCε Inhibitor Peptide acetate
🥰Excellent
Catalog No. T35827L
Alias PKCε Inhibitor Peptide acetate(182683-50-7 Free base)
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC.
PKCε Inhibitor Peptide acetate
🥰Excellent
Purity: 98.93%
Catalog No. T35827LAlias PKCε Inhibitor Peptide acetate(182683-50-7 Free base)
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 2 mg | $86 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $196 | In Stock | |
| 25 mg | $331 | In Stock | |
| 50 mg | $476 | In Stock | |
| 100 mg | $653 | In Stock | |
| 200 mg | $879 | In Stock |
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CitedSelect Batch
Purity:98.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-, and δPKC. |
| In vitro | PKCε Inhibitor Peptide acetate(1 µM; 24 hours) significantly inhibits Oleic acid-induced connexin 43 Ser368 phosphorylation and prevents Oleic acid-induced gap junction disassembly in cardiomyocytes[1]. |
| In vivo | In C57BL/6J mice transplanted the hearts of FVB mice, PKCε Inhibitor Peptide acetate (20 mg/kg/day; osmotic pumps s.c.) significantly improved the beating score throughout the treatment. PKCε Inhibitor Peptide acetate treatment almost abolished the rise in pro-fibrotic cytokine, TGF-β, and monocyte recruiting chemokine MCP-1 levels. PKCε Inhibitor Peptide acetate reduced the infiltration of macrophages and T cells into the cardiac grafts and decreased parenchymal fibrosis[2]. |
| Alias | PKCε Inhibitor Peptide acetate(182683-50-7 Free base) |
| Molecular Weight | 904.02 |
| Formula | C39H69N9O15 |
| Smiles | C[C@@H](O)[C@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCC(O)=O)=O)C)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CCCCN)=O)=O)C(O)=O.CC(O)=O |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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