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A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1], and also inhibits PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM), and myosin light chain kinase (MLCK) (Ki=7.4 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $61 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $173 | In Stock | |
50 mg | $289 | In Stock | |
100 mg | $463 | In Stock | |
500 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $92 | In Stock |
Description | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1], and also inhibits PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM), and myosin light chain kinase (MLCK) (Ki=7.4 μM). |
Targets&IC50 | PKA:4.3 μM (ki), PKC:47 μM (ki), CK1:80 μM (ki), CK2:5.1 μM (ki) |
In vitro | A-3 hydrochloride competitively inhibits MLC-kinase with respect to ATP, with a Ki value of 7.4 μM. It also competitively inhibits cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II with ATP, exhibiting Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
Molecular Weight | 321.22 |
Formula | C12H14Cl2N2O2S |
Cas No. | 78957-85-4 |
Smiles | Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (389.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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