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Procyanidin A1

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Purity:99.23%

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COA HPLC HNMR

Procyanidin A1

Catalog No. TN1136Cas No. 103883-03-0

Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.

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Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$247	In Stock
10 mg	$369	In Stock
25 mg	$615	In Stock
50 mg	$869	In Stock
100 mg	$1,170	In Stock
1 mL x 10 mM (in DMSO)	$312	In Stock

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Product Introduction

Bioactivity

Description	Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.
In vitro	We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na]?. Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1[1]
Alias	Proanthocyanidin A1

Chemical Properties

Molecular Weight	576.5
Formula	C30H24O12
Cas No.	103883-03-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (95.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7346 mL	8.6730 mL	17.3461 mL	86.7303 mL
5 mM	0.3469 mL	1.7346 mL	3.4692 mL	17.3461 mL
10 mM	0.1735 mL	0.8673 mL	1.7346 mL	8.6730 mL
20 mM	0.0867 mL	0.4337 mL	0.8673 mL	4.3365 mL
50 mM	0.0347 mL	0.1735 mL	0.3469 mL	1.7346 mL

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