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NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.
Pack Size | Price | Availability | Quantity |
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1 mg | $42 | In Stock | |
5 mg | Inquiry | In Stock |
Description | NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis. |
Targets&IC50 | Ezrin T567:8.1 μM |
In vitro | NSC668394, when pretreated at 10 μM for 15 minutes, inhibits ezrin T567 phosphorylation (IC50=8.1 μM) and in vitro actin binding[2]. Additionally, at concentrations ranging from 1 to 10 μM for 2 to 6 hours, NSC668394 inhibits ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells into HUVEC monolayers[2]. Furthermore, at a concentration of 20 μM, NSC668394 significantly reduces the growth of JM1 and JM2 rat hepatocellular carcinoma cell lines[1]. Notably, NSC668394 at 10 μM diminishes cell motility phenotypes in zebrafish[2]. |
In vivo | Administered at a dose of 0.226 mg/kg/day through weekly intraperitoneal injections for 5 days, NSC668394 inhibits ezrin protein-dependent in vivo metastatic growth in the lungs of mice[2]. |
Alias | NSC-668394, NSC 668394 |
Molecular Weight | 452.1 |
Formula | C17H12Br2N2O3 |
Cas No. | 382605-72-3 |
Smiles | Oc1c(Br)cc(CCNC2=CC(=O)c3cccnc3C2=O)cc1Br |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (66.36 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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