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NSC668394

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Catalog No. T28212Cas No. 382605-72-3
Alias NSC-668394, NSC 668394

NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.

NSC668394

NSC668394

🥰Excellent
Purity: 99.29%
Catalog No. T28212Alias NSC-668394, NSC 668394Cas No. 382605-72-3
NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.
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Purity:99.29%
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Product Introduction

Bioactivity
Description
NSC668394 is a potent small molecule ezrin (Thr567) phosphorylation inhibitor.NSC668394 has potential antitumor activity by inhibiting ezrin T567 phosphorylation and increasing Ca2+-dependent ezrin cleavage.NSC668394 can be used to study tumor metastasis.
Targets&IC50
Ezrin T567:8.1 μM
In vitro
NSC668394, when pretreated at 10 μM for 15 minutes, inhibits ezrin T567 phosphorylation (IC50=8.1 μM) and in vitro actin binding[2]. Additionally, at concentrations ranging from 1 to 10 μM for 2 to 6 hours, NSC668394 inhibits ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells into HUVEC monolayers[2]. Furthermore, at a concentration of 20 μM, NSC668394 significantly reduces the growth of JM1 and JM2 rat hepatocellular carcinoma cell lines[1].
Notably, NSC668394 at 10 μM diminishes cell motility phenotypes in zebrafish[2].
In vivo
Administered at a dose of 0.226 mg/kg/day through weekly intraperitoneal injections for 5 days, NSC668394 inhibits ezrin protein-dependent in vivo metastatic growth in the lungs of mice[2].
AliasNSC-668394, NSC 668394
Chemical Properties
Molecular Weight452.1
FormulaC17H12Br2N2O3
Cas No.382605-72-3
SmilesOc1c(Br)cc(CCNC2=CC(=O)c3cccnc3C2=O)cc1Br
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (66.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2119 mL11.0595 mL22.1190 mL110.5950 mL
5 mM0.4424 mL2.2119 mL4.4238 mL22.1190 mL
10 mM0.2212 mL1.1060 mL2.2119 mL11.0595 mL
20 mM0.1106 mL0.5530 mL1.1060 mL5.5298 mL
50 mM0.0442 mL0.2212 mL0.4424 mL2.2119 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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