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Desmethylglycitein
Catalog No. TN1299Cas No. 17817-31-1
Alias 6,7,4'-Trihydroxyisoflavone
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
Desmethylglycitein
Catalog No. TN1299Alias 6,7,4'-TrihydroxyisoflavoneCas No. 17817-31-1
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $188 | In Stock | |
| 5 mg | $568 | In Stock | |
| 10 mg | $752 | In Stock | |
| 25 mg | $1,160 | In Stock | |
| 50 mg | $1,570 | In Stock | |
| 100 mg | $2,110 | In Stock | |
| 500 mg | $4,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $466 | In Stock |
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Purity:97.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
| In vitro | Molecular studies showed that Desmethylglycitein significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that Desmethylglycitein significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice. |
| In vivo | A single administration of Desmethylglycitein significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.Moreover, treatment with Desmethylglycitein alone enhanced learning and memory performance in the same behavioral tests. Desmethylglycitein improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
| Alias | 6,7,4'-Trihydroxyisoflavone |
| Molecular Weight | 270.24 |
| Formula | C15H10O5 |
| Cas No. | 17817-31-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (462.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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