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Bisindolylmaleimide VIII
🥰Excellent
Catalog No. T71125Cas No. 125313-65-7
Alias RO 318161, Ro 31-7549, Bis VIII
Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Bisindolylmaleimide VIII
🥰Excellent
Purity: 98.01%
Catalog No. T71125Alias RO 318161, Ro 31-7549, Bis VIIICas No. 125313-65-7
Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Purity:98.01%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism. |
| Targets&IC50 | PKC (rat brain):158 nM, PKCβI:195 nM, PKCγ:213 nM, PKCε:175 nM, PKCβII:163 nM, PKCα:53 nM |
| In vitro | Ro-31-7549 (5 μM; 8, 12h; 1321N1 cells) significantly increases TRA-8-induced cell death in a time- and dose-dependent manner.[2] After combined treatment with Ro-31-7549 (5 μM; 6h; 1321N1 cells) and TRA-8, procaspase-8 was significantly reduced at 4 h and completely disappeared at 6h.[2] |
| In vivo | Ro-31-7549 (100 μg; i.p.; every other day for three doses; 6-8-week-old female NOD/SCID mice) combined with toTRA-8, resulted in nearly complete tumor regression. Bisindolylmaleimide VIII alone did not result in significant tumor regression.[2] |
| Alias | RO 318161, Ro 31-7549, Bis VIII |
| Molecular Weight | 398.46 |
| Formula | C24H22N4O2 |
| Cas No. | 125313-65-7 |
| Smiles | O=C1NC(=O)C(C2=CN(C=3C=CC=CC23)CCCN)=C1C4=CN(C=5C=CC=CC45)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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