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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,870 | 10-14 weeks | |
50 mg | $3,780 | 10-14 weeks | |
100 mg | $5,200 | 10-14 weeks |
Description | AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM). |
In vitro | AS2521780 effectively inhibits CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and the proliferation of human primary T cells. Additionally, it impedes concanavalin A-induced cytokine production in rat splenocytes and monkey peripheral blood mononuclear cells with comparable efficacy[1]. The compound demonstrates a potent inhibition of recombinant human PKCθ enzyme activity, with an IC50 value of 0.48 nM, showcasing more than a 30-fold selective inhibition over other PKC isoforms. Moreover, AS2521780 exhibits minimal or no inhibitory effects on other protein kinases. |
In vivo | AS2521780 markedly diminishes paw swelling through a dose-dependent mechanism in a rat model of adjuvant-induced arthritis[1]. |
Molecular Weight | 547.76 |
Formula | C30H41N7OS |
Cas No. | 1214726-89-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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