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AS2521780
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Catalog No. T14328Cas No. 1214726-89-2
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
AS2521780
😃Good
Catalog No. T14328Cas No. 1214726-89-2
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 2.726 € | 10-14 weeks | |
| 50 mg | 3.591 € | 10-14 weeks | |
| 100 mg | 4.940 € | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM). |
| Targets&IC50 | PKCα:160 nM, PKCδ:160 nM, PKCθ:0.48 nM, PKCε:18 nM |
| In vitro | AS2521780 effectively inhibits CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and the proliferation of human primary T cells. Additionally, it impedes concanavalin A-induced cytokine production in rat splenocytes and monkey peripheral blood mononuclear cells with comparable efficacy[1]. The compound demonstrates a potent inhibition of recombinant human PKCθ enzyme activity, with an IC50 value of 0.48 nM, showcasing more than a 30-fold selective inhibition over other PKC isoforms. Moreover, AS2521780 exhibits minimal or no inhibitory effects on other protein kinases. |
| In vivo | AS2521780 markedly diminishes paw swelling through a dose-dependent mechanism in a rat model of adjuvant-induced arthritis[1]. |
| Molecular Weight | 547.76 |
| Formula | C30H41N7OS |
| Cas No. | 1214726-89-2 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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