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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $35 | In Stock | |
10 mg | $55 | In Stock | |
25 mg | $118 | In Stock |
Description | Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation. |
In vitro | Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2]. |
In vivo | Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3]. |
Alias | Mallotoxin, NSC 56346, NSC 94525 |
Molecular Weight | 516.54 |
Formula | C30H28O8 |
Cas No. | 82-08-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 2 mg/mL (3.87 mM) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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