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Sangivamycin

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Purity:98.11%

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COA HPLC HNMR

Sangivamycin

Catalog No. T9605Cas No. 18417-89-5

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

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Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$347	In Stock
10 mg	$528	In Stock
25 mg	$859	In Stock
50 mg	$1,190	In Stock
100 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$382	In Stock

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Product Introduction

Bioactivity

Description	Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
In vitro	Sangivamycin (0.3 μM; 0-72 hours) exhibits a predominantly cytocidal effect in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, and a cytostatic effect in drug-sensitive MCF7/wild type (WT) cells. In MCF7/ADR cells, Sangivamycin triggers caspase activation, leading to significant cleavage of lamin A into a 28-kDa fragment within 48 hours. These findings highlight Sangivamycin's differential antitumor activities, inducing apoptosis-driven cell death in MCF7/ADR cells and growth arrest in MCF7/WT cells.
Alias	BA-90912, NSC 65346

Chemical Properties

Molecular Weight	309.28
Formula	C12H15N5O5
Cas No.	18417-89-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (307.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2333 mL	16.1666 mL	32.3332 mL	161.6658 mL
5 mM	0.6467 mL	3.2333 mL	6.4666 mL	32.3332 mL
10 mM	0.3233 mL	1.6167 mL	3.2333 mL	16.1666 mL
20 mM	0.1617 mL	0.8083 mL	1.6167 mL	8.0833 mL
50 mM	0.0647 mL	0.3233 mL	0.6467 mL	3.2333 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc