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Adenosine

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Catalog No. T0853Cas No. 58-61-7
Alias D-Adenosine, Adenine riboside

Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.

Adenosine

Adenosine

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Purity: 99.92%
Catalog No. T0853Alias D-Adenosine, Adenine ribosideCas No. 58-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
Pack SizePriceAvailabilityQuantity
500 mg$46In Stock
1 g$55In Stock
5 g$87Backorder
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
In vitro
METHODS: Human prostate cancer cells DU-145, PC3 and LNcap-FGC-10 were treated with Adenosine (0.1-1000 µM) for 48 h. Cell viability was measured by MTT assay.
RESULTS: Adenosine significantly reduced cell proliferation of DU-145, PC3 and LNcap-FGC10 cell lines in a dose-dependent manner. [1]
METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Adenosine (2 mM) for 6-24 h. The cell cycle was detected by Flow cytometry.
RESULTS: Adenosine-induced inhibition of survival was attributed to the arrest of cell cycle progression. Adenosine significantly increased the percentage of G0/G1-phase cells and decreased the percentage of S-phase and G2/M-phase cells in HepG2 cells. [2]
In vivo
METHODS: To investigate the antidepressant-like effects, Adenosine (1-10 mg/kg) was intraperitoneally injected into mice and subjected to the forced swimming test (FST) and tail suspension test (TST).
RESULTS: The immobilization time in the FST was shortened by intraperitoneal injection of Adenosine (5-10 mg/kg), and Adenosine (1-10 mg/kg) also produced antidepressant-like effects in the TST. [3]
AliasD-Adenosine, Adenine riboside
Chemical Properties
Molecular Weight267.24
FormulaC10H13N5O4
Cas No.58-61-7
SmilesNC1=NC=NC2=C1N=CN2C1OC(CO)C(O)C1O
Relative Density.1.3382 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (75 mM)
H2O: 2.7 mg/mL (10 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.7420 mL18.7098 mL37.4195 mL187.0977 mL
5 mM0.7484 mL3.7420 mL7.4839 mL37.4195 mL
10 mM0.3742 mL1.8710 mL3.7420 mL18.7098 mL
DMSO
1mg5mg10mg50mg
20 mM0.1871 mL0.9355 mL1.8710 mL9.3549 mL
50 mM0.0748 mL0.3742 mL0.7484 mL3.7420 mL

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