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BJE6-106
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Catalog No. T10555Cas No. 1564249-38-2
Alias B106
BJE6-106 (B106) is a potent and selective PKCδ inhibitor with an IC50 of 0.05 μM, demonstrating significant selectivity over classical PKCα (IC50: 50 μM). It induces caspase-dependent apoptosis and has a tumor-specific effect.
BJE6-106
😃Good
Catalog No. T10555Alias B106Cas No. 1564249-38-2
BJE6-106 (B106) is a potent and selective PKCδ inhibitor with an IC50 of 0.05 μM, demonstrating significant selectivity over classical PKCα (IC50: 50 μM). It induces caspase-dependent apoptosis and has a tumor-specific effect.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,140 | 6-8 weeks | |
| 50 mg | $1,490 | 6-8 weeks | |
| 100 mg | $2,320 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $365 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BJE6-106 (B106) is a potent and selective PKCδ inhibitor with an IC50 of 0.05 μM, demonstrating significant selectivity over classical PKCα (IC50: 50 μM). It induces caspase-dependent apoptosis and has a tumor-specific effect. |
| Targets&IC50 | PKCα:50 μM, PKCδ:0.05 μM |
| In vitro | BJE6-106 (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing JNK, MKK4, and H2AX activation at different times in SBcl2 cells. |
| Alias | B106 |
| Molecular Weight | 381.47 |
| Formula | C26H23NO2 |
| Cas No. | 1564249-38-2 |
| Relative Density. | 1.16 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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