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CRT0066854 hydrochloride
🥰Excellent
Catalog No. T10888Cas No. 2250019-91-9
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
CRT0066854 hydrochloride
🥰Excellent
Purity: 97.51%
Catalog No. T10888Cas No. 2250019-91-9
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $46 | In Stock | |
| 10 mg | $76 | In Stock | |
| 25 mg | $129 | In Stock | |
| 50 mg | $191 | In Stock | |
| 100 mg | $275 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $56 | In Stock |
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CitedSelect Batch
Purity:97.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
| Targets&IC50 | ROCKII:620 nM, PKCζ:639 nM |
| In vitro | CRT0066854 hydrochloride replaces the crucial Asn-Phe-Asp motif, which is part of the adenosine binding pocket and joins with the acidic patch used by the PKC substrate rich in arginine. CRT0066854 hydrochloric acid Salt (0.2-1.2μM; 6 days) can restore polarized morphogenesis. Among the dysplastic H-Ras spheroids, the maximum proportion of PSAL spheroids was 1.2 μM at a lower dose[1]. |
| Molecular Weight | 488.48 |
| Formula | C24H27Cl2N5S |
| Cas No. | 2250019-91-9 |
| Smiles | N[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(CCCC4)SC3=NC(C5=CC=NC=C5)=N2.Cl.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (92.12 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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