PKC-IN-1

Name: PKC-IN-1
Brand: TargetMol
SKU: T12494
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively).

Catalog No. T12494Cas No. 1046787-18-1

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Purity:98.79%

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COA HPLC

PKC-IN-1

Catalog No. T12494Cas No. 1046787-18-1

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$198	In Stock
5 mg	$347	8-10 weeks
25 mg	$1,140	8-10 weeks
50 mg	$1,490	8-10 weeks
100 mg	$1,990	8-10 weeks
1 mL x 10 mM (in DMSO)	$383	8-10 weeks

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Product Introduction

Bioactivity

Description	PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively).
Targets&IC50	PKCβII (human):7.6 nM, PKCβ (human):5.3 nM (ki), PKCθ (human):25.6 nM, PKCμ (human):314 nM, PKCβI (human):8.1 nM, PKCγ (human):57.5 nM, PKCε (human):808 nM, PKCα (human):10.4 nM (ki), PKCα (human):2.3 nM
In vitro	PKC-IN-1 is a potent, ATP-competitive, and reversible of conventional PKC enzymes (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively) [1].
In vivo	In Lewis rats, PKC-IN-1 dose-dependently and significantly reduces maximum EAE severity and end severity in the autoimmune encephalitis (EAE) model [1].

Chemical Properties

Molecular Weight	500.61
Formula	C₂₅H₃₇FN₈O₂
Cas No.	1046787-18-1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (49.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9976 mL	9.9878 mL	19.9756 mL	99.8781 mL
5 mM	0.3995 mL	1.9976 mL	3.9951 mL	19.9756 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL	9.9878 mL
20 mM	0.0999 mL	0.4994 mL	0.9988 mL	4.9939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc