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UCN-02
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Catalog No. T17198Cas No. 121569-61-7
Alias 7-epi-Hydroxystaurosporine
UCN-02 (7-epi-Hydroxystaurosporine) is a selective and highly potent protein kinase C (PKC) inhibitor produced by Streptomyces N-126 strain, inhibiting PKA. UCN-02 has antitumor activity.
UCN-02
😃Good
Catalog No. T17198Alias 7-epi-HydroxystaurosporineCas No. 121569-61-7
UCN-02 (7-epi-Hydroxystaurosporine) is a selective and highly potent protein kinase C (PKC) inhibitor produced by Streptomyces N-126 strain, inhibiting PKA. UCN-02 has antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $945 | 35 days | |
| 5 mg | $3,428 | 35 days |
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Concentration:1.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | UCN-02 (7-epi-Hydroxystaurosporine) is a selective and highly potent protein kinase C (PKC) inhibitor produced by Streptomyces N-126 strain, inhibiting PKA. UCN-02 has antitumor activity. |
| Targets&IC50 | PKC:0.062 μM, PKA:0.25 μM |
| In vitro | UCN-02 has been shown to inhibit PKC and PKA with IC50 values of 0.062 and 0.25 μM. UCN-02 also showed the cytotoxic effect on the growth of HeLa S3 cells. [1] UCN-02 dose-response experiments point to a more marked effect on cyst growth than general organoid growth. [3] |
| Alias | 7-epi-Hydroxystaurosporine |
| Molecular Weight | 482.53 |
| Formula | C28H26N4O4 |
| Cas No. | 121569-61-7 |
| Smiles | C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)[C@H](O)NC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8 |
| Relative Density. | 1.63 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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