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SB220025
🥰Excellent
Catalog No. T28681Cas No. 165806-53-1
Alias SB-220025, SB 220025
SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis.
SB220025
🥰Excellent
Catalog No. T28681Alias SB-220025, SB 220025Cas No. 165806-53-1
SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis. |
| Targets&IC50 | PKC:2.89 µM, p56Lck:3.5 µM, p38 MAPK (human):60 nM |
| In vitro | SB220025 is an ATP-competitive and selective inhibitor of human p38 MAPK with an IC50 of 60 nM. p56Lck and PKC were also inhibited by SB220025 with IC50s of 3.5 and 2.89 µM, respectively. [2] SB220025 (20 μM; 6 h) significantly reduced IL-8 gene expression in HUVEC cells in response to globular adiponectin (gAd). [1] |
| In vivo | A single oral dose of 3-50 mg/kg SB220025 inhibited the production of inflammatory cytokines in vivo . Intraperitoneal administration of 5, 30, and 50 mg/kg SB220025 in a double dose inhibited angiogenesis in a mouse model of air sac granuloma . Oral administration of 30 mg/kg SB220025, given as a double dose for 3, 5, 7, or 14 days prevented the increase in angiogenesis after day 3 in the mouse air sac angiogenesis model . Oral administration of 50 mg/kg SB220025, double-dosed for 10 days, effectively inhibited the progression of arthritis in a chronic inflammatory disease model . [2] |
| Alias | SB-220025, SB 220025 |
| Molecular Weight | 338.38 |
| Formula | C18H19FN6 |
| Cas No. | 165806-53-1 |
| Smiles | FC1=CC=C(C=C1)C=2N=CN(C2C=3N=C(N=CC3)N)C4CCNCC4 |
| Relative Density. | 1.42 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (295.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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