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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $322 | In Stock | |
50 mg | $478 | In Stock | |
100 mg | $689 | In Stock | |
500 mg | $1,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $116 | In Stock |
Description | MW-150 (MW01-18-150SRM) is a unique, selective, CNS-penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. |
Targets&IC50 | p38α:101 nM (Ki) |
In vitro | MW-150 treatment blocked in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50?values for these MW150 cellular activities are 332 nM (MK2) and 936 nM (IL-1β), values which are consistent with the in vitro?Ki?of 101 nM for p38αMAPK. |
Animal Research | MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice |
Alias | MW01-18-150SRM |
Molecular Weight | 381.47 |
Formula | C24H23N5 |
Cas No. | 1628502-91-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 6.25 mg/mL (16.38 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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