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MW-150 dihydrochloride dihydrate

Catalog No. T5487 CAS 1661020-92-3

MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active p38α MAPK inhibitor with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia [1].

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MW-150 dihydrochloride dihydrate Chemical Structure

MW-150 dihydrochloride dihydrate, CAS 1661020-92-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active p38α MAPK inhibitor with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia [1].
In vitro	MW-150 dihydrochloride dihydrate concentration-dependently inhibits the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia [1]. MW-150 dihydrochloride dihydrate blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC 50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively [1].
In vivo	MW-150 dihydrochloride dihydrate administered orally at a dosage of 2.5 mg/kg daily for 3 to 4 months enhances cognitive abilities in APP/PS1 transgenic mice, as evidenced by improved performance in the radial arm water maze (RAWM) and contextual fear conditioning tests. Similarly, when given intraperitoneally (i.p.) at the same dosage for 14 days, this treatment normalizes RAWM behavior in APP NLh/NLh × PS P264L/P264L knock-in mice, which do not overexpress the amyloid precursor protein, making their performance comparable to that of wild-type (WT) mice.

Molecular Weight	490.43
Formula	C24H29Cl2N5O2
CAS No.	1661020-92-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MW-150 dihydrochloride dihydrate 1661020-92-3 MW-150 MW150 dihydrochloride dihydrate MW150 MW-150 dihydrochloride Dihydrate MW 150 dihydrochloride dihydrate MW 150 inhibitor inhibit

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