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MW-150 dihydrochloride dihydrate

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Catalog No. T5487Cas No. 1661020-92-3

MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS-penetrant, and orally active p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the endogenous p38α MAPK's ability to phosphorylate the endogenous substrate MK2 in activated glia [1].

MW-150 dihydrochloride dihydrate

MW-150 dihydrochloride dihydrate

😃Good
Catalog No. T5487Cas No. 1661020-92-3
MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS-penetrant, and orally active p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the endogenous p38α MAPK's ability to phosphorylate the endogenous substrate MK2 in activated glia [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5201-2 weeks
50 mg$1,9801-2 weeks
100 mg$2,5001-2 weeks
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Product Introduction

Bioactivity
Description
MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS-penetrant, and orally active p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the endogenous p38α MAPK's ability to phosphorylate the endogenous substrate MK2 in activated glia [1].
In vitro
MW-150 dihydrochloride dihydrate concentration-dependently inhibits the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia [1]. MW-150 dihydrochloride dihydrate blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC 50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively [1].
In vivo
MW-150 dihydrochloride dihydrate administered orally at a dosage of 2.5 mg/kg daily for 3 to 4 months enhances cognitive abilities in APP/PS1 transgenic mice, as evidenced by improved performance in the radial arm water maze (RAWM) and contextual fear conditioning tests. Similarly, when given intraperitoneally (i.p.) at the same dosage for 14 days, this treatment normalizes RAWM behavior in APP NLh/NLh × PS P264L/P264L knock-in mice, which do not overexpress the amyloid precursor protein, making their performance comparable to that of wild-type (WT) mice.
Chemical Properties
Molecular Weight490.43
FormulaC24H29Cl2N5O2
Cas No.1661020-92-3
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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