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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $40 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $349 | In Stock | |
100 mg | $576 | In Stock | |
1 mL x 10 mM (in DMSO) | $75 | In Stock |
Description | CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. |
Targets&IC50 | CDK9-CyclinT:13 nM, VEGFR2:84 nM, CDK7-CyclinH:200 nM, CDK4-CyclinD:216 nM, CDK2-CyclinE:3 nM, CDK5-p25:10 nM, CDK1-CyclinB:26 nM, CDK2-CyclinA:4 nM |
In vitro | The IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK5/p25, CDK7/CyclinH, CDK4/CyclinD and CDK9/cycT, respectively[4]. |
In vivo | In the LPS endotoxemia model, CGP60474 (10?mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate[3]. |
Molecular Weight | 355.82 |
Formula | C18H18ClN5O |
Cas No. | 164658-13-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (140.52 mM) H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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