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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $44 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $96 | In Stock | |
25 mg | $166 | In Stock | |
50 mg | $266 | In Stock | |
100 mg | $460 | In Stock | |
200 mg | $598 | In Stock | |
1 mL x 10 mM (in DMSO) | $78 | In Stock |
Description | Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively) |
In vitro | Afuresertib-induced p21 expression promotes G1 phase arrest by inducing FOXO activity.?Furthermore, afuresertib significantly enhanced cisplatin-induced cytotoxicity.Afuresertib modulated the expression E2F1 and MYC, which are associated with fibroblast core serum response.?Suggest that afuresertib is a useful anticancer drug for treating patients with MPM[1]. |
Cell Research | Cell confluence proliferation assay was performed using Incucyte ZOOM Live‐Cell Imaging System.?Briefly, ACC‐MESO‐4 and MSTO‐211H cells were seeded in 12‐well plates (cell density, 1 × 104 cells/well) and were incubated for 24 h at 37°C.?Then, the cells were incubated with 0, 2, 5, or 10 μmol/L afuresertib.?During treatment, cell growth was monitored by recording phase images using the IncuCyte ZOOM Live‐Cell Imaging System (magnification, ×100)[1]. |
Molecular Weight | 463.8 |
Formula | C18H18Cl3FN4OS |
Cas No. | 1047645-82-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (215.62 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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