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HBDDE

HBDDE
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Purity:98.03%
ee:100%
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HBDDE

Catalog No. T39030Cas No. 154675-18-0
HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells.
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Pack SizePriceAvailabilityQuantity
1 mg$297In Stock
5 mg$728In Stock
10 mg$993In Stock
25 mg$1,470In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Product Introduction

Bioactivity
Description
HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells.
Targets&IC50
PKCγ:50 μM (IC50), PKCα:43 μM (IC50)
In vitro
HBDDE (50 μM; 5 h; Cerebellar granule cells) leads to a substantial reduction in cell viability by approximately 70%. Additionally, HBDDE demonstrates a notable augmentation in caspase-3 activity.[1]
Chemical Properties
Molecular Weight338.31
FormulaC16H18O8
Cas No.154675-18-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.5 mg/mL (13.3 mM)
H2O: 0.9 mg/mL (2.7 mM)
Ethanol: 0.9 mg/mL (2.7 mM)
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9559 mL14.7793 mL29.5587 mL147.7934 mL

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