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Y-33075 dihydrochloride is a selective inhibitor of ROCK with an IC50 of 3.6 nM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $109 | In Stock | |
25 mg | $213 | In Stock | |
50 mg | $379 | In Stock | |
100 mg | $567 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Y-33075 dihydrochloride is a selective inhibitor of ROCK with an IC50 of 3.6 nM. |
Targets&IC50 | CaMK II:810 nM, ROCK:3.6 nM, PKC:420 nM |
In vitro | Y-33075 (Y-39983) is a potent inhibitor of ROCK with an IC50 of 3.6 nM and exhibits greater inhibitory effects on PKC and CaMKII compared to Y-27632. The IC50 values for PKC are 9.0 μM for Y-27632 and 0.42 μM for Y-33075, while for CaMKII, the IC50s are 26 μM and 0.81 μM, respectively. The IC50s for Y-27632 and Y-33075 for PKC are 82 and 117 times higher than for ROCK, respectively, and for CaMKII, they are 236 and 225 times higher than for ROCK, respectively [1]. Y-33075 (Y-39983, 10 μM) promotes neurite extension in retinal ganglion cells (RGCs) compared to untreated cells [2], and at 1 μM, it inhibits the histamine-evoked contraction of rabbit ciliary artery segments in Ca2+-free solutions [3]. |
In vivo | Y-33075 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-33075 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys[1]. Y-33075 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats[2]. |
Molecular Weight | 353.25 |
Formula | C16H18Cl2N4O |
Cas No. | 173897-44-4 |
Smiles | Cl.Cl.C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12 |
Relative Density. | no data available |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (283.09 mM), Sonication is recommended. H2O: 50 mg/mL (141.54 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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