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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | In Stock | |
5 mg | $192 | In Stock | |
10 mg | $285 | In Stock | |
25 mg | $482 | In Stock | |
50 mg | $687 | In Stock | |
100 mg | $955 | In Stock | |
1 mL x 10 mM (in DMSO) | $198 | In Stock |
Description | Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes. |
Targets&IC50 | PKC:20 nM, PKCβ1:6.2 nM, PKC:7.9 nM, PKCα:2.3 nM |
In vitro | 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2] |
Alias | Gö 6976 |
Molecular Weight | 378.43 |
Formula | C24H18N4O |
Cas No. | 136194-77-9 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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