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D8-MMAF hydrochloride

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D8-MMAF hydrochloride

Catalog No. T19269

D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.

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Pack Size	Price	Availability
1 mg	$971	Backorder
5 mg	$2,202	Backorder
10 mg	$4,136	Backorder
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder

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Questions

Product Introduction

Bioactivity

Description	D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.
In vitro	MMAF showed cytotoxicity in vitro against a group of cell lines. Karpas 299, H3396, 786-O and Caki-1 have IC50 values of 119, 105, 257 and 200 nM, respectively. Targeted MMAF is more effective than free drug, and the cAC10 conjugate of MMAF shows significant activity. On a molar basis, cAC10-L1-MMAF4 is on average more than 2200 times more potent than free MMAF and is active in all CD30-positive cell lines tested.
In vivo	The maximum tolerated dose of MMAF (> 16 mg / kg) mice is much higher than that of MMAE (1 mg / kg). The MTD of cAC10-L1-MMAF4 is 50 mg / kg in mice and 15 mg / kg in rats. The corresponding cAC10-L4-MMAF4 ADC is much less toxic, with MTDs greater than 150 mg / kg and 90 mg / kg in mice and rats, respectively.

Chemical Properties

Molecular Weight	776.47
Formula	C39H58D8ClN5O8
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

D-8-MMAF hydrochlorideD8 MMAF hydrochlorideD8MMAF hydrochlorideD8-MMAF Hydrochloride