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D8-MMAF hydrochloride
Catalog No. T19269
D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.
D8-MMAF hydrochloride
Catalog No. T19269
D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $971 | Backorder | |
| 5 mg | $2,202 | Backorder | |
| 10 mg | $4,136 | Backorder | |
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule destroyer. |
| In vitro | MMAF showed cytotoxicity in vitro against a group of cell lines. Karpas 299, H3396, 786-O and Caki-1 have IC50 values of 119, 105, 257 and 200 nM, respectively. Targeted MMAF is more effective than free drug, and the cAC10 conjugate of MMAF shows significant activity. On a molar basis, cAC10-L1-MMAF4 is on average more than 2200 times more potent than free MMAF and is active in all CD30-positive cell lines tested. |
| In vivo | The maximum tolerated dose of MMAF (> 16 mg / kg) mice is much higher than that of MMAE (1 mg / kg). The MTD of cAC10-L1-MMAF4 is 50 mg / kg in mice and 15 mg / kg in rats. The corresponding cAC10-L4-MMAF4 ADC is much less toxic, with MTDs greater than 150 mg / kg and 90 mg / kg in mice and rats, respectively. |
| Molecular Weight | 776.47 |
| Formula | C39H58D8ClN5O8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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