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D8-MMAD

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D8-MMAD

Catalog No. T10947

D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.

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Pack Size	Price	Availability
1 mg	$971	Backorder
5 mg	$2,202	Backorder
10 mg	$4,136	Backorder
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$3,546	Backorder

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Product Introduction

Bioactivity

Description	D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.
In vitro	MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro.
In vivo	The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.
Alias	Monomethylauristatin D D8, Demethyldolastatin 10 D8, Monomethyl Dolastatin 10 D8

Chemical Properties

Molecular Weight	779.11
Formula	C41H58D8N6O6S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (128.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2835 mL	6.4176 mL	12.8352 mL	64.1758 mL
5 mM	0.2567 mL	1.2835 mL	2.5670 mL	12.8352 mL
10 mM	0.1284 mL	0.6418 mL	1.2835 mL	6.4176 mL
20 mM	0.0642 mL	0.3209 mL	0.6418 mL	3.2088 mL
50 mM	0.0257 mL	0.1284 mL	0.2567 mL	1.2835 mL
100 mM	0.0128 mL	0.0642 mL	0.1284 mL	0.6418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

D-8-MMADD8MMADD8 MMADD8-MMAD