Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $971 | Backorder | |
5 mg | $2,202 | Backorder | |
10 mg | $4,136 | Backorder | |
50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder | |
1 mL x 10 mM (in DMSO) | $3,546 | Backorder |
Description | D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer. |
In vitro | MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro. |
In vivo | The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved. |
Alias | Monomethylauristatin D D8, Demethyldolastatin 10 D8, Monomethyl Dolastatin 10 D8 |
Molecular Weight | 779.11 |
Formula | C41H58D8N6O6S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (128.35 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.