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Palbociclib-d8
🥰Excellent
Catalog No. T12355Cas No. 1628752-83-9
Alias PD0332991 D8, PD 0332991 D8, Palbociclib D8
Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
Palbociclib-d8
🥰Excellent
Catalog No. T12355Alias PD0332991 D8, PD 0332991 D8, Palbociclib D8Cas No. 1628752-83-9
Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $489 | In Stock | |
| 5 mg | $1,080 | In Stock | |
| 10 mg | $1,620 | In Stock | |
| 25 mg | $2,750 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer. |
| Targets&IC50 | MAPK:8000 nM, DYRK1A:2000 nM, CDK4-CyclinD1:11 nM, CDK6-CyclinD2:16 nM, CDK4-CyclinD3:9 nM |
| Alias | PD0332991 D8, PD 0332991 D8, Palbociclib D8 |
| Molecular Weight | 455.58 |
| Formula | C24H21D8N7O2 |
| Cas No. | 1628752-83-9 |
| Smiles | O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4C(C(NC(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N2)C5CCCC5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 5 mg/mL (10.98 mM), when pH is adjusted to 3 with 1M HCl, sonication and heating are recommended. DMSO: 1 mg/mL (2.2 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/H2O
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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