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Palbociclib-d8

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Catalog No. T12355Cas No. 1628752-83-9
Alias PD 0332991 D8, Palbociclib D8

Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).

Palbociclib-d8
Other Forms of Palbociclib-d8:

Palbociclib-d8

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Catalog No. T12355Alias PD 0332991 D8, Palbociclib D8Cas No. 1628752-83-9
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
Pack SizePriceAvailabilityQuantity
1 mg$25935 days
5 mgInquiry7-10 days
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Product Introduction

Bioactivity
Description
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
Targets&IC50
CDK4-CyclinD1:11 nM, CDK6-CyclinD2:16 nM, CDK4-CyclinD3:9 nM, DYRK1A:2000 nM, MAPK:8000 nM
AliasPD 0332991 D8, Palbociclib D8
Chemical Properties
Molecular Weight455.58
FormulaC24H29N7O2
Cas No.1628752-83-9
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Palbociclib-d-8Palbociclib-d8Palbociclibd8MAPKDYRK1ACdk6/cyclin D2Cdk4/cyclin D3Cdk4/cyclin D1
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