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Palbociclib hydrochloride
🥰Excellent
Catalog No. T63576Cas No. 571189-11-2
Alias TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride
Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
Palbociclib hydrochloride
🥰Excellent
Purity: 99.89%
Catalog No. T63576Alias TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochlorideCas No. 571189-11-2
Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $31 | In Stock | |
| 5 mg | $47 | In Stock | |
| 10 mg | $73 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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CitedSelect Batch
Purity:99.89%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Palbociclib hydrochloride (pabociclib hydrochloride) is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor with anti-tumor proliferative activity for use in breast and hepatocellular carcinoma. |
| Targets&IC50 | CDK4-CyclinD3:9 nM, CDK6-CyclinD2:16 nM, MAPK:8000 nM, Dyrk1A:2000 nM, CDK4-CyclinD1:11 nM |
| In vitro | Methods: Huh7 and skHep1 cells were treated with Palbociclib hydrochloride (0.1, 0.5 μM, 10 days) to test the reversibility of cell cycle arrest. Results: Palbociclib hydrochloride may induce irreversible cell cycle arrest in both cell lines, which may be dose-dependent. [2] |
| In vivo | Methods: Palbociclib hydrochloride (40 mg/kg, oral, 17 days) was used to treat NSG mice bearing IMR32 neuroblastoma cells to study its effect on tumor growth in mice. Results: Palbociclib hydrochloride effectively inhibited tumor growth in NSG mice and had no obvious toxicity to mice. [1] |
| Alias | TQB-3616 hydrochloride, TQB3616 hydrochloride, PD-0332991 hydrochloride, PD0332991 hydrochloride |
| Molecular Weight | 520.46 |
| Formula | C24H31Cl2N7O2 |
| Cas No. | 571189-11-2 |
Storage & Solubility Information
| Storage | keep away from moisture | store at 4°C | Shipping with blue ice. | ||||||||||
| Solubility Information | H2O: 1.00 mg/mL (1.92 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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