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Isoliquiritigenin

Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.

Catalog No. T0725Cas No. 961-29-5

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Purity:99.44%

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Isoliquiritigenin

Catalog No. T0725Cas No. 961-29-5

Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.

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Pack Size	Price	Availability	Quantity
20 mg	$50	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.
Targets&IC50	Aldose reductase:320 nM
In vitro	METHODS: Normal human hepatocyte cell line LO2 and HCC cell line Hep3B were treated with Isoliquiritigenin (30-60 µM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Isoliquiritigenin showed significant cytotoxicity against Hep3B cells with an IC50 of 42.84±2.01 µM at 48 h. This effect was concentration and time dependent. However, at the same Isoliquiritigenin stimulation intensity, the survival of LO2 cells was significantly less affected with an IC50 >60 µM.[1] METHODS: Human colorectal cancer cells HCT-116 were treated with Isoliquiritigenin (20 µM) for 24 h. Apoptosis was detected by Flow cytometry. RESULTS: Treatment of HCT-116 cells with Isoliquiritigenin resulted in a significant increase in apoptosis (17.26%) in the treated group compared to the NC group (7.37%). [2]
In vivo	METHODS: To assay anti-tumor activity in vivo, Isoliquiritigenin (50 mg/kg) was injected intraperitoneally into BALB/c-nu/nu mice bearing Hep3B xenografts once daily for three weeks. RESULTS: Isoliquiritigenin-treated mice had reduced tumor burden in terms of mean tumor size or xenograft weight. [1]
Alias	ISL, Isoliquiritigen, GU17

Chemical Properties

Molecular Weight	256.25
Formula	C₁₅H₁₂O₄
Cas No.	961-29-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (234.15 mM)

Ethanol: 22 mg/mL (85.9 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9024 mL	19.5122 mL	39.0244 mL	195.1220 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL	39.0244 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL	19.5122 mL
20 mM	0.1951 mL	0.9756 mL	1.9512 mL	9.7561 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9024 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9512 mL

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