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Zopolrestat

🥰Excellent
Catalog No. T35317Cas No. 110703-94-1
Alias Zopolrestatum, CP-73850, CP73850, CP 73850

Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

Zopolrestat

Zopolrestat

🥰Excellent
Purity: 98.09%
Catalog No. T35317Alias Zopolrestatum, CP-73850, CP73850, CP 73850Cas No. 110703-94-1
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$40In Stock
5 mg$64In Stock
10 mg$93In Stock
25 mg$213In Stock
50 mg$345In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Purity:98.09%
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Product Introduction

Bioactivity
Description
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Targets&IC50
Aldose reductase:3.1 nM
In vitro
Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1].
In vivo
After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1].
AliasZopolrestatum, CP-73850, CP73850, CP 73850
Chemical Properties
Molecular Weight419.38
FormulaC19H12F3N3O3S
Cas No.110703-94-1
SmilesOC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12
Relative Density.1.58g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (26.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3845 mL11.9224 mL23.8447 mL119.2236 mL
5 mM0.4769 mL2.3845 mL4.7689 mL23.8447 mL
10 mM0.2384 mL1.1922 mL2.3845 mL11.9224 mL
20 mM0.1192 mL0.5961 mL1.1922 mL5.9612 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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