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Tolrestat
🥰Excellent
Catalog No. T17114Cas No. 82964-04-3
Alias AY-27773
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
Tolrestat
🥰Excellent
Purity: 100%
Catalog No. T17114Alias AY-27773Cas No. 82964-04-3
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 38 € | In Stock | |
| 5 mg | 88 € | In Stock | |
| 10 mg | 148 € | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM). |
| Targets&IC50 | Aldose reductase:35 nM |
| In vivo | The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats[1]. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice[2]. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels[3]. |
| Alias | AY-27773 |
| Molecular Weight | 357.35 |
| Formula | C16H14F3NO3S |
| Cas No. | 82964-04-3 |
| Smiles | C(N(CC(O)=O)C)(=S)C=1C2=C(C(C(F)(F)F)=C(OC)C=C2)C=CC1 |
| Relative Density. | 1.399 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (279.84 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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