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Alpha-Estradiol

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Purity:99.69%

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COA HNMR HPLC

Alpha-Estradiol

Catalog No. T3378Cas No. 57-91-0

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

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Pack Size	Price	Availability
100 mg	$50	In Stock
500 mg	$83	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

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Product Introduction

Bioactivity

Description	Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
Kinase Assay	Na+-Ca2+ exchange activity is determined by assaying Na+-dependent 45Ca2+ uptake as reported previously. Briefly, the cells are preincubated in Hanks' balanced saline solution (HBSS) for 20 min, and the medium is switched to HBSS containing 45Ca2+?and incubated for 5 min. To increase intracellular Na+?concentration, 1 mM ouabain plus 20 μM monensin (for astrocytes and microglia) and 10 μM monensin (for neurons) are used. Monensin is added simultaneously with the isotope. Ouabain is added 5 min before monensin in astrocytes and microglia. SEA0400 and KB-R7943 are added 5 min before monensin and present during 45Ca2+?uptake reaction.
Alias	Alfatradiol, 17α-Estradiol, Epiestrol, Epiestradiol

Chemical Properties

Molecular Weight	272.38
Formula	C18H24O2
Cas No.	57-91-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (165.21 mM)

Ethanol: 100 mM

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6713 mL	18.3567 mL	36.7134 mL	183.5671 mL
5 mM	0.7343 mL	3.6713 mL	7.3427 mL	36.7134 mL
10 mM	0.3671 mL	1.8357 mL	3.6713 mL	18.3567 mL
20 mM	0.1836 mL	0.9178 mL	1.8357 mL	9.1784 mL
50 mM	0.0734 mL	0.3671 mL	0.7343 mL	3.6713 mL
100 mM	0.0367 mL	0.1836 mL	0.3671 mL	1.8357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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