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Lidorestat
🥰Excellent
Catalog No. T15756Cas No. 245116-90-9
Alias IDD-676
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
Lidorestat
🥰Excellent
Purity: 99.84%
Catalog No. T15756Alias IDD-676Cas No. 245116-90-9
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $108 | In Stock | |
| 50 mg | $165 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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Purity:99.84%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes. |
| Targets&IC50 | Rldose reductase:5 nM |
| In vitro | Lidorestat's reported IC50 value for recombinant human aldose reductase (/h/-ALR2) in in vitro experiments is 5 μM. against recombinant human aldehyde reductase (/h/-ALR1), the selectivity ratio of /h/-ALR1 to /h/-ALR2 is 5400:1 [1,2]. |
| In vivo | Lidorestat (25 mg/kg/day, oral administration, twice daily for 6 weeks) reduces fructose levels and lowers mortality rates in diabetic, hAR-expressing mice without affecting weight.[1] |
| Alias | IDD-676 |
| Molecular Weight | 376.35 |
| Formula | C18H11F3N2O2S |
| Cas No. | 245116-90-9 |
| Smiles | OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12 |
| Relative Density. | 1.55g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (132.86 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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