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Dutasteride
🥰Excellent
Catalog No. T1499Cas No. 164656-23-9
Alias GI 198745, GG 745, Avodart
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
Dutasteride
🥰Excellent
Purity: 99.58%
Catalog No. T1499Alias GI 198745, GG 745, AvodartCas No. 164656-23-9
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $32 | In Stock | |
| 10 mg | $52 | In Stock | |
| 25 mg | $80 | In Stock | |
| 50 mg | $107 | In Stock | |
| 100 mg | $162 | In Stock | |
| 200 mg | $226 | In Stock | |
| 500 mg | $379 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock |
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Purity:99.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. |
| In vitro | In healthy male rats, daily treatment with Dutasteride (100mg/kg) resulted in a prostate size that was half the size of that in control rats. |
| In vivo | Dutasteride effectively inhibits Type I 5AR (IC50=6 nM) and Type II 5AR (IC50=7 nM). In LNCaP cells (IC50=1 μM), it suppresses DHT-induced PSA secretion and proliferation, and competes for androgen receptor (AR) binding (IC50=1.5 μM). Additionally, dutasteride reduces cell viability and proliferation in both androgen-responsive (LNCaP) and androgen-nonresponsive (DU145) human prostate cancer (PCa) cell lines. |
| Alias | GI 198745, GG 745, Avodart |
| Molecular Weight | 528.53 |
| Formula | C27H30F6N2O2 |
| Cas No. | 164656-23-9 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H] |
| Relative Density. | 1.303 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 6 mg/mL (11.35 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (113.52 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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