Fidarestat

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

Catalog No. T15281Cas No. 136087-85-9

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Fidarestat

Catalog No. T15281Cas No. 136087-85-9

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

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Pack Size	Price	Availability
1 mg	$268	35 days
5 mg	$1,189	35 days
10 mg	$2,108	35 days

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Product Introduction

Bioactivity

Description	Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
Targets&IC50	Aldose reductase:26 nM, AKR1B10:33 μM, AKR1B10 (V301L):1.8 μM
In vivo	Fidarestat (1 or 4 mg/kg. p.o., daily for 4 weeks) decreases the concentrations of sorbitol and fructose in diabetic rats [2].
Alias	SNK 860

Chemical Properties

Molecular Weight	279.22
Formula	C₁₂H₁₀FN₃O₄
Cas No.	136087-85-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (895.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5814 mL	17.9070 mL	35.8141 mL	179.0703 mL
5 mM	0.7163 mL	3.5814 mL	7.1628 mL	35.8141 mL
10 mM	0.3581 mL	1.7907 mL	3.5814 mL	17.9070 mL
20 mM	0.1791 mL	0.8954 mL	1.7907 mL	8.9535 mL
50 mM	0.0716 mL	0.3581 mL	0.7163 mL	3.5814 mL
100 mM	0.0358 mL	0.1791 mL	0.3581 mL	1.7907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc