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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $73 | In Stock | |
5 mg | $158 | In Stock | |
10 mg | $249 | In Stock | |
25 mg | $463 | In Stock | |
50 mg | $683 | In Stock | |
100 mg | $973 | In Stock | |
1 mL x 10 mM (in DMSO) | $173 | In Stock |
Description | AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats. |
Targets&IC50 | Aldose reductase:100 pM |
In vivo | AT-007 markedly reduces galactitol levels across all target tissues (liver, brain, and plasma) in GALT null rats, without elevating galactose or Gal-1P concentrations [2]. |
Molecular Weight | 425.4 |
Formula | C17H10F3N3O3S2 |
Cas No. | 2170729-29-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 35.71 mg/mL (83.94 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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