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Beta-lactamase

Beta-lactamase is an enzyme produced by certain bacteria that provides resistance to beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. These antibiotics contain a beta-lactam ring, which is essential for their antibacterial activity. Beta-lactamase catalyzes the hydrolysis of the beta-lactam ring, rendering the antibiotic inactive and allowing bacteria to survive.

Metallo-β-lactamase-IN-16
T2010212058069-25-1
Metallo-β-lactamase-IN-16 (compound 18), a sulfone-containing metallo-β-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-β-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.
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