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Oxiconazole
🥰Excellent
Catalog No. T20693Cas No. 64211-45-6
Alias Ro13-8996 free base, Ro-13-8996 free base, Oxiconazolum
Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.
Oxiconazole
🥰Excellent
Purity: 99.99%
Catalog No. T20693Alias Ro13-8996 free base, Ro-13-8996 free base, OxiconazolumCas No. 64211-45-6
Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock |
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Purity:99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration. |
| In vitro | Methods: HCT116, RKO, DLD-1, SW620, SW480 and LoVo cells were treated with oxiconazole (10, 20, 30, 40 μM, 24 hours), and cell viability was determined by MTT assay. Results: Oxiconazole significantly inhibited the growth of these cells. [1] |
| In vivo | Methods: Oxiconazole (50 mg/kg, intraperitoneal injection, 12 days treatment) was used in nude mice with CRC xenograft model to confirm its antitumor activity against CRC in vivo. Results: Oxiconazole treatment reduced tumor size, tumor weight and growth rate of CRC xenografts. [1] |
| Alias | Ro13-8996 free base, Ro-13-8996 free base, Oxiconazolum |
| Molecular Weight | 429.13 |
| Formula | C18H13Cl4N3O |
| Cas No. | 64211-45-6 |
| Smiles | Clc1ccc(CO\N=C(/Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 |
| Relative Density. | 1.42 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (11.65 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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