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AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 60 € | In Stock | |
10 mg | 92 € | In Stock | |
25 mg | 166 € | In Stock | |
50 mg | 282 € | In Stock | |
100 mg | 424 € | In Stock | |
1 mL x 10 mM (in DMSO) | 66 € | In Stock |
Description | AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator. |
In vivo | AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1]. |
Animal Research | Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1] |
Alias | AZD-7325 |
Molecular Weight | 354.38 |
Formula | C19H19FN4O2 |
Cas No. | 942437-37-8 |
Smiles | CCCNC(=O)c1nnc2c(cccc2c1N)-c1c(F)cccc1OC |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 9 mg/mL (25.4 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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