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Search Results for " anxiety "

Targets

135

Compounds

9

Natural Products

8

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T8318 BNC210 H-Ile-Trp-OH,IW-2143 AChR
BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
T22994 ML 154 Neuropeptide Y Receptor
neuropeptide S receptor (NPSR) antagonist
T2200 Hydroxyzine dihydrochloride Hydroxyzine 2HCl Histamine Receptor
Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIR...
T7061 Duloxetine Serotonin Transporter
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
T1997 JNJ-31020028 JNJ 31020028 Neuropeptide Y Receptor
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors.
T16421 P-MPPI hydrochloride 5-HT Receptor
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
T3183 SAX-187 WAY 181187,WAY181187 5-HT Receptor
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.
T6043 PF-3845 FAAH , Autophagy
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
T16472 Pericyazine Propericiazine,RP 8909 Dopamine Receptor
Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych...
T8004 SNAP 94847 hydrochloride GPR , Melanin-concentrating Hormone Receptor (MCHR)
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)
T9272 Xaliproden hydrochloride Dopamine Receptor , 5-HT Receptor
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist.
T2710 TCS 1102 OX Receptor
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T21011 Buspirone Buspirone free base,Ansial 5-HT Receptor
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor.
T7644 DPN Diarylpropionitrile Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T2067 NS11394 NS 11394 GABA Receptor
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.
T2463 ML141 CID-2950007 Apoptosis , CDK , Ras
ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
T7699 AZD7325 AZD-7325 P450 , GABA Receptor
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
T21654 1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl lysophosphatidic acid sodium salt LPA Receptor
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2
T2132 Buspirone hydrochloride Buspirone HCl,Narol,Buspar Dopamine Receptor , 5-HT Receptor
Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T1471 Duloxetine hydrochloride Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i...
T5406 SNAP 94847 SNAP-94847 GPR , Melanin-concentrating Hormone Receptor (MCHR)
SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.
T1696 2-(1-Piperazinyl)pyrimidine Adrenergic Receptor
2-(1-Piperazinyl)pyrimidine is used as an anti-anxiety drug.
T26559 ACT-462206 OX Receptor
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
T7136 AZD-6280 GABA Receptor
AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder.
T26600 Alpidem Ananxyl GABA Receptor
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin...
T25672 Lesopitron 5-HT Receptor
Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withd...
T0715 Chlormezanone Trancopal Others , GABA Receptor
Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
T0240 Trimetozine Sedoxazine,Trioxazin Others
Trimetozine (Sedoxazine) is a sedative that has been marketed in Europe since 1959. It has mild tranquilizing effects and has been used to treat anxiety.
T27186 Divaplon RU-32698,RU32698,RU 32698 GABA Receptor
Divaplon is a GABA receptor agonist (IC50: 0.056 µM) that displays non-sedating anxiolytic behavioral characteristics in a rat model of anxiety.
T23444 TCS 1105 N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide Others
TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice.
T13110 Tedatioxetine hydrobromide Lu AA 24530 hydrobromide Dopamine Receptor , 5-HT Receptor , Norepinephrine
Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress...
T68172 Zalospirone 5-HT Receptor
Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.
T1077 Fluvoxamine maleate MK-264,DU-23000 (maleate) 5-HT Receptor , Serotonin Transporter
Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
T68142 Serazapine 5-HT Receptor
Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders.
T27262 Enciprazine WY-48624,D-3112,WY48624,WY 48624,D 3112,D3112 5-HT Receptor
Enciprazine (D-3112) has anxiolytic activity with high affinity for 5-HT1A receptor and ADRA1, which can be used for the treatment of anxiety disorders and can be used to study depression.
T67954 Endixaprine SR 41378
Endixaprine (SR 41378) is a small molecule compound used to treat neurological disorders and may be used to study anxiety disorders and epilepsy.
T67966 Triflubazam
Triflubazam has a wide range of biological activities that can affect sleep and can be used to treat anxiety syndromes and psychological disorders.
T68154 TC-2216 AChR
TC-2216 is a partial agonist at the neural nicotinic acetylcholine receptor and is used to treat anxiety and depression.
T31592 E6801 E 6801,E-6801 5-HT Receptor
E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases...
T22442 Trazodone AF-1161 5-HT Receptor
Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.
T90597 SSR504734 HCl
SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 ( IC 50 =18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety and depression models [1].
T5828 MS21570 GPR
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice.
T26646 AQW051 AQ W051,VQW-765,AQW-051 AChR
AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac...
T28294 Panadiplon FG10571,FG-10571,FD-10571,PNU 78875,FG 10571,FD10571,FD 10571 GABA Receptor
Panadiplon (FG 10571) is a selective gamma-aminobutyric acid receptor agonist and partial agonist of 5GABAA, a benzodiazepine receptor, used in the treatment of anxiety disorders.Panadiplon exhibits selectivity for 5GABA...
T22453 Venlafaxine Wy 45030 Serotonin Transporter
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
T29645 Adatanserin hydrochloride WY50324 hydrochloride 5-HT Receptor
Adatanserin hydrochloride (WY50324 hydrochloride) is a novel 5-HT(1A)/5-HT(2) receptor ligand with potential neuroprotective effects and inhibition of ischemic efflux of endogenous amino acids, which can be used in the s...
T35707 3'-Sialyllactose sodium 3'-SL sodium NF-κB
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation...
TP1981L Neuropeptide S (Mouse) acetate Neuropeptide Y Receptor
Neuropeptide S (Mouse) acetate is a bioactive peptide. Neuropeptide S (Mouse) acetate, as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behavio...
TNU0187 2',5-Difluoro-2'-deoxy-1-arabinosyluracil 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine Nucleoside Antimetabolite/Analog
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study an...
T1619 Trazodone hydrochloride KB-831,Trazodone HCl,AF-1161 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi...

Compounds

BNC210
T8318
Synonym: H-Ile-Trp-OH,IW-2143
Target: AChR
ML 154
T22994
Synonym:
Target: Neuropeptide Y Receptor
Hydroxyzine dihydrochloride
T2200
Synonym: Hydroxyzine 2HCl
Target: Histamine Receptor
Duloxetine
T7061
Synonym:
Target: Serotonin Transporter
JNJ-31020028
T1997
Synonym: JNJ 31020028
Target: Neuropeptide Y Receptor
p-MPPI hydrochloride
T16421
Synonym:
Target: 5-HT Receptor
SAX-187
T3183
Synonym: WAY 181187,WAY181187
Target: 5-HT Receptor
PF-3845
T6043
Synonym:
Target: FAAH, Autophagy
Pericyazine
T16472
Synonym: Propericiazine,RP 8909
Target: Dopamine Receptor
SNAP 94847 hydrochloride
T8004
Synonym:
Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)
Xaliproden hydrochloride
T9272
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
TCS 1102
T2710
Synonym:
Target: OX Receptor
Buspirone
T21011
Synonym: Buspirone free base,Ansial
Target: 5-HT Receptor
DPN
T7644
Synonym: Diarylpropionitrile
Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
NS11394
T2067
Synonym: NS 11394
Target: GABA Receptor
ML141
T2463
Synonym: CID-2950007
Target: Apoptosis, CDK, Ras
AZD7325
T7699
Synonym: AZD-7325
Target: P450, GABA Receptor
1-Oleoyl lysophosphatidic acid sodium
T21654
Synonym: 1-Oleoyl lysophosphatidic acid sodium salt
Target: LPA Receptor
Buspirone hydrochloride
T2132
Synonym: Buspirone HCl,Narol,Buspar
Target: Dopamine Receptor, 5-HT Receptor
Duloxetine hydrochloride
T1471
Synonym: Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine
SNAP 94847
T5406
Synonym: SNAP-94847
Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)
2-(1-Piperazinyl)pyrimidine
T1696
Synonym:
Target: Adrenergic Receptor
ACT-462206
T26559
Synonym:
Target: OX Receptor
AZD-6280
T7136
Synonym:
Target: GABA Receptor
Alpidem
T26600
Synonym: Ananxyl
Target: GABA Receptor
Lesopitron
T25672
Synonym:
Target: 5-HT Receptor
Chlormezanone
T0715
Synonym: Trancopal
Target: Others, GABA Receptor
Trimetozine
T0240
Synonym: Sedoxazine,Trioxazin
Target: Others
Divaplon
T27186
Synonym: RU-32698,RU32698,RU 32698
Target: GABA Receptor
TCS 1105
T23444
Synonym: N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide
Target: Others
Tedatioxetine hydrobromide
T13110
Synonym: Lu AA 24530 hydrobromide
Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine
Zalospirone
T68172
Synonym:
Target: 5-HT Receptor
Fluvoxamine maleate
T1077
Synonym: MK-264,DU-23000 (maleate)
Target: 5-HT Receptor, Serotonin Transporter
Serazapine
T68142
Synonym:
Target: 5-HT Receptor
Enciprazine
T27262
Synonym: WY-48624,D-3112,WY48624,WY 48624,D 3112,D3112
Target: 5-HT Receptor
Endixaprine
T67954
Synonym: SR 41378
Target:
Triflubazam
T67966
Synonym:
Target:
TC-2216
T68154
Synonym:
Target: AChR
E6801
T31592
Synonym: E 6801,E-6801
Target: 5-HT Receptor
Trazodone
T22442
Synonym: AF-1161
Target: 5-HT Receptor
SSR504734 HCl
T90597
Synonym:
Target:
MS21570
T5828
Synonym:
Target: GPR
AQW051
T26646
Synonym: AQ W051,VQW-765,AQW-051
Target: AChR
Panadiplon
T28294
Synonym: FG10571,FG-10571,FD-10571,PNU 78875,FG 10571,FD10571,FD 10571
Target: GABA Receptor
Venlafaxine
T22453
Synonym: Wy 45030
Target: Serotonin Transporter
Adatanserin hydrochloride
T29645
Synonym: WY50324 hydrochloride
Target: 5-HT Receptor
3'-Sialyllactose sodium
T35707
Synonym: 3'-SL sodium
Target: NF-κB
Neuropeptide S (Mouse) acetate
TP1981L
Synonym:
Target: Neuropeptide Y Receptor
2',5-Difluoro-2'-deoxy-1-arabinosyluracil
TNU0187
Synonym: 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine
Target: Nucleoside Antimetabolite/Analog
Trazodone hydrochloride
T1619
Synonym: KB-831,Trazodone HCl,AF-1161
Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor
1 2 3
Cat No. Product Name Synonyms Targets
T20884 Hydroxyzine Hydroxyzine free base Histamine Receptor
Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor.
TN2004 Obtusin MAO , Monoamine Oxidase
Obtusin is a natural product.
T4939 Indole-3-pyruvic acid 3-(3-Indolyl)-2-oxopropanoic acid Others
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta...
T4S1999 Valepotriate Valtrate Apoptosis , HIV Protease
Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agen...
T4814 (R)-5-Oxopyrrolidine-2-carboxylic acid D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid Others , Endogenous Metabolite
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di...
T2O2777 L-Threonine threonine Others , Endogenous Metabolite
L-Threonine (threonine) is an essential amino acid in humans,an important amino acid for the nervous system,L-Threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. ...
T68953 Arecoline Reactive Oxygen Species , AChR
Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can in...
T2940 6-Hydroxyflavone 6-HF GABA Receptor
6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydro...
TCS2170 2,5-Dihydroxyacetophenone Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP ERK , NF-κB , Tyrosinase
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02374 LSAMP Protein, Human, Recombinant (hFc) Human HEK293
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system struct...
TMPY-02383 LSAMP Protein, Human, Recombinant (His) Human HEK293
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system struct...
TMPY-02924 RGS1 Protein, Human, Recombinant (His) Human E. coli
RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization o...
TMPY-03991 DBI Protein, Human, Recombinant (His) Human E. coli
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece...
TMPY-01618 GLO1 Protein, Mouse, Recombinant (His) Mouse E. coli
Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyox...
TMPY-02648 PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) Human HEK293
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate...
TMPH-03256 CNR1 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...
TMPH-01035 CNR1 Protein-VLP, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
Cat No. Product Name
L6820 Tobacco Monomer Library

750 compounds
A unique collection of 750 tobacco monomer compounds for high throughput screening and high content screening;
TargetMol