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ATC 0175 hydrochloride

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Purity:99.84%

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COA HPLC HNMR

ATC 0175 hydrochloride

Catalog No. T22591Cas No. 510733-97-8

ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.

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Pack Size	Price	Availability
1 mg	$72	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$538	In Stock
50 mg	$913	In Stock
100 mg	$1,490	In Stock
500 mg	$2,990	In Stock

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Product Introduction

Bioactivity

Description	ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.
In vitro	In vitro, assays showed that this compound is a potent antagonist with a high affinity for MCH1R. The receptor binding and the functional assay (MCH-induced increase in [Ca2+]) indicated that ATC0175 is a noncompetitive antagonist at MCH1Rs.[1]
In vivo	ATC0175 (1, 3, 10 mg/kg ; p.o. ) treatment also exhibited antidepressant effects in the forced swimming test.[2] ATC0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia.[2]

Chemical Properties

Molecular Weight	461.93
Formula	C23H26ClF2N5O
Cas No.	510733-97-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 22.5 mg/mL (48.7 mM)

DMSO: 9.0 mg/mL (19.4 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1648 mL	10.8242 mL	21.6483 mL	108.2415 mL
5 mM	0.4330 mL	2.1648 mL	4.3297 mL	21.6483 mL
10 mM	0.2165 mL	1.0824 mL	2.1648 mL	10.8242 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1082 mL	0.5412 mL	1.0824 mL	5.4121 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1648 mL
100 mM	0.0216 mL	0.1082 mL	0.2165 mL	1.0824 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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