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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $68 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $263 | In Stock | |
25 mg | $476 | In Stock | |
50 mg | $715 | In Stock | |
100 mg | $987 | In Stock |
Description | SSR504734 is an orally active, selective, and reversible inhibitor of human, rat, and mouse GlyT1 (IC50 = 18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety, and depression models [1]. |
In vitro | SSR504734 (15 nM-86 μM; 10 min) inhibits the ex vivo uptake of glycine in human SK-N-MC and rat C6 cells, with IC50 values of 18 nM and 15 nM, respectively [1]. |
In vivo | SSR504734 (i.p. and p.o.; 1-100 mg/kg; once) demonstrates good oral bioavailability with ID50 values of 5.0 and 4.6 mg/kg for i.p. and p.o. treatments, respectively [1]. At 30 mg/kg (i.p.; once), it maintains approximately 80% inhibition of specific glycine uptake from 1 to 7 hours post-administration [1]. At 10 mg/kg (i.p.; once), it rapidly and significantly increases extracellular glycine levels in the prefrontal cortex of freely moving male Sprague-Dawley rats [1]. |
Molecular Weight | 433.30 |
Formula | C20H21Cl2F3N2O |
Cas No. | 615571-23-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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