Shopping Cart
- Remove All
Your shopping cart is currently empty
ACT-462206
🥰Excellent
Catalog No. T26559Cas No. 1361321-96-1
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
ACT-462206
🥰Excellent
Purity: 99.45%
Catalog No. T26559Cas No. 1361321-96-1
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $139 | In Stock | |
| 25 mg | $293 | In Stock | |
| 50 mg | $469 | In Stock | |
| 100 mg | $745 | In Stock | |
| 500 mg | $1,490 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "ACT-462206"
Seltorexant
JNJ-42847922
T12877L1293281-49-8
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).
- $31
Size
QTY
PF3274167
PF-3274167, PF 3274167, Cligosiban
T3347900510-03-4
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
- $30
Size
QTY
TCS 1102
DORA-1
T2710916141-36-1
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
- $34
Size
QTY
Orexin B, rat, mouse Acetate
Rat orexin B, Orexin B, rat, mouse Acetate(202801-92-1 free base), Orexin B (mouse) Acetate
TP1045L
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
- $185
Size
QTY
IPSU
T55031373765-19-5
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
- $47
Size
QTY
MK-3697
T19131224846-01-8
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
- $44
Size
QTY
L-368,899 hydrochloride
L-368899 hydrochloride, L-368,899 HCl
T11794160312-62-9
L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression.
- $113
Size
QTY
Filorexant
MK-6096
T160961088991-73-4
Filorexant (MK-6096) is an orally bioavailable, effective, and selective reversible antagonist of OX1 and OX2 receptors, with (Ki <3 nM).
- $30
Size
QTY
OXA (17-33) acetate
TP1973L
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
- $293
Size
QTY
YNT-185
T392291804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
- $60
Size
QTY
DORA-22
T55001088991-95-0
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
- $133
Size
QTY
Orexin 2 Receptor Agonist
OX2R
T31771796565-52-0
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
- $35
Size
QTY
Select Batch
Purity:99.45%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. |
| In vivo | In male Wistar rats, ACT-462206 (0, 10, 30, 100, 300 mg/kg; oral gavage; single dose) decreased the duration of the first non-rapid eye movement (NREM) sleep episode (60 seconds) and the first rapid eye movement (REM) sleep episode (30 seconds). Furthermore, ACT-462206 dose-dependently reduced total wake time and behavioral home cage activity, while increasing both REM and NREM sleep durations[1]. |
| Molecular Weight | 388.48 |
| Formula | C20H24N2O4S |
| Cas No. | 1361321-96-1 |
| Smiles | COc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1C(=O)Nc1cc(C)cc(C)c1 |
| Relative Density. | 1.285 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (205.93 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy ACT-462206 | purchase ACT-462206 | ACT-462206 cost | order ACT-462206 | ACT-462206 chemical structure | ACT-462206 in vivo | ACT-462206 formula | ACT-462206 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.