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L-368,899 hydrochloride
L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression.
Catalog No. T11794Cas No. 160312-62-9
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Purity:99.59%
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L-368,899 hydrochloride
Catalog No. T11794Cas No. 160312-62-9
L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $113 | In Stock | |
| 5 mg | $158 | In Stock | |
| 10 mg | $255 | In Stock | |
| 25 mg | $487 | In Stock | |
| 50 mg | $762 | In Stock | |
| 100 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $223 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression. |
| Targets&IC50 | OTR (human uterus):26 nM, OTR (rat uterus):8.9 nM |
| In vitro | L-368,899 hydrochloride is an effective non-peptide oxytocin receptor antagonist, with IC50 values of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptors, respectively[1]. |
| In vivo | L-368,899 (5 mg/kg; oral administration) has oral bioavailabilities of 14% and 18% in female and male rats, respectively[2]. |
| Alias | L-368899 hydrochloride, L-368,899 HCl |
| Molecular Weight | 591.23 |
| Formula | C26H43ClN4O5S2 |
| Cas No. | 160312-62-9 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (3.38 mM), Sonication is recommended. DMSO: 100 mg/mL (169.14 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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