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YNT-185
🥰Excellent
Catalog No. T39229Cas No. 1804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
YNT-185
🥰Excellent
Purity: 98.6%
Catalog No. T39229Cas No. 1804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $239 | In Stock | |
| 25 mg | $478 | In Stock | |
| 50 mg | $772 | In Stock | |
| 100 mg | $1,050 | In Stock |
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Purity:98.6%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. |
| Targets&IC50 | OX1R:2.75 μM(EC50), OX2R:0.028(EC50) |
| In vivo | YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for 3 hours and reduces non-rapid eye movement (NREM) sleep duration in wild-type mice but not in OXRDKO mice.[1] |
| Molecular Weight | 615.74 |
| Formula | C33H37N5O5S |
| Cas No. | 1804978-81-1 |
| Smiles | S(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 62.0 mg/mL (90.0 mM) H2O: Insoluble  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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