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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $239 | In Stock | |
25 mg | $478 | In Stock | |
50 mg | $772 | In Stock | |
100 mg | $1,050 | In Stock |
Description | YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. |
In vivo | YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice.[1]. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for a period of 3 hours, accompanied by a reduction in non-rapid eye movement (NREM) sleep duration, in wild-type mice but not in OXRDKO mice.[1] |
Molecular Weight | 615.74 |
Formula | C33H37N5O5S |
Cas No. | 1804978-81-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 62.0 mg/mL (90.0 mM) H2O: Insoluble ![]() | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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