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IPSU

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Purity:98.1%

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COA HNMR HPLC

IPSU

Catalog No. T5503Cas No. 1373765-19-5

IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$49	In Stock
5 mg	$78	In Stock
10 mg	$98	In Stock
25 mg	$211	In Stock
50 mg	$315	In Stock
100 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Product Introduction

Bioactivity

Description	IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
In vitro	BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1].
In vivo	IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2]

Chemical Properties

Molecular Weight	405.49
Formula	C23H27N5O2
Cas No.	1373765-19-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (73.98 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4662 mL	12.3308 mL	24.6615 mL	123.3076 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL	24.6615 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL	12.3308 mL
20 mM	0.1233 mL	0.6165 mL	1.2331 mL	6.1654 mL
50 mM	0.0493 mL	0.2466 mL	0.4932 mL	2.4662 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc