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(S)-UFR2709 hydrochloride
🥰Excellent
Catalog No. T37094Cas No. 2934318-93-9
(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist with higher affinity for α4β2 nAChRs than for α7 nAChRs. It decreases anxiety and reduces ethanol consumption and preference in alcohol-preferring rats. As an anxiolytic agent, (S)-UFR2709 (hydrochloride) can be used for the study of nicotine addiction[1][2].
(S)-UFR2709 hydrochloride
🥰Excellent
Purity: 98.94%
Catalog No. T37094Cas No. 2934318-93-9
(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist with higher affinity for α4β2 nAChRs than for α7 nAChRs. It decreases anxiety and reduces ethanol consumption and preference in alcohol-preferring rats. As an anxiolytic agent, (S)-UFR2709 (hydrochloride) can be used for the study of nicotine addiction[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $81 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $247 | In Stock | |
| 50 mg | $372 | In Stock | |
| 100 mg | $579 | In Stock | |
| 500 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $84 | In Stock |
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Purity:98.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist with higher affinity for α4β2 nAChRs than for α7 nAChRs. It decreases anxiety and reduces ethanol consumption and preference in alcohol-preferring rats. As an anxiolytic agent, (S)-UFR2709 (hydrochloride) can be used for the study of nicotine addiction[1][2]. |
| In vitro | Brain nicotinic acetylcholine receptors (nAChRs), a diverse group of pentameric acetylcholine-gated cation channels, serve as a molecular target for alcohol abuse and dependence treatment[1]. |
| In vivo | (S)-UFR2709 (hydrochloride) (50-100 μg/ml) administered for 3 minutes and then held for 5 minutes significantly reduces bottom dwelling time in the Novel Tank Test (NTT), showing a dose-dependent decrease to 52.9 and 87.0 seconds for 50 and 100 μg/ml, respectively [2]. This compound also diminishes nicotine-evoked mRNA expression of the α4 nACh receptor subunit in adult zebrafish brains, with a lesser effect at both concentrations [2]. Additionally, intraperitoneal injection at 1-10 mg/kg daily for 17 days in high-alcohol-drinking UChB rats significantly decreases ethanol consumption and preference, while increasing water consumption dose-dependently, with 2.5 mg/kg being the most effective, resulting in a 56% reduction in alcohol intake, without impacting weight or locomotor activity [1]. |
| Molecular Weight | 255.74 |
| Formula | C13H18ClNO2 |
| Cas No. | 2934318-93-9 |
| Smiles | C(OC(=O)C1=CC=CC=C1)[C@H]2N(C)CCC2.Cl |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (195.51 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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