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(S)-UFR2709 hydrochloride

Catalog No. T37094Cas No. 2934318-93-9

(S)-UFR2709 hydrochloride ((S)-UFR2709 HCl) is a selective and potent nAChR antagonist with anxiolytic activity, inhibits α4β2 nAChR and α7 nAChR, and can be used to study nicotine addiction.

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Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$123	In Stock
25 mg	$247	In Stock
50 mg	$372	In Stock
100 mg	$579	In Stock
500 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Product Introduction

Bioactivity

Description	(S)-UFR2709 hydrochloride ((S)-UFR2709 HCl) is a selective and potent nAChR antagonist with anxiolytic activity, inhibits α4β2 nAChR and α7 nAChR, and can be used to study nicotine addiction.
In vitro	Brain nicotinic acetylcholine receptors (nAChRs), a diverse group of pentameric acetylcholine-gated cation channels, serve as a molecular target for alcohol abuse and dependence treatment[1].
In vivo	In high-alcohol-drinking UChB rats, (S)-UFR2709 hydrochloride (10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg; intraperitoneal injection; daily; for 17 days) did not affect body weight or locomotor activity but reduced ethanol consumption[1].

Chemical Properties

Molecular Weight	255.74
Formula	C13H18ClNO2
Cas No.	2934318-93-9

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (195.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9102 mL	19.5511 mL	39.1022 mL	195.5111 mL
5 mM	0.7820 mL	3.9102 mL	7.8204 mL	39.1022 mL
10 mM	0.3910 mL	1.9551 mL	3.9102 mL	19.5511 mL
20 mM	0.1955 mL	0.9776 mL	1.9551 mL	9.7756 mL
50 mM	0.0782 mL	0.3910 mL	0.7820 mL	3.9102 mL
100 mM	0.0391 mL	0.1955 mL	0.3910 mL	1.9551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc