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Org-12962

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Purity:98.34%

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COA HNMR HPLC

Org-12962

Catalog No. T16401Cas No. 132834-56-1

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).

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Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$56	In Stock
25 mg	$83	In Stock
50 mg	$113	In Stock
100 mg	$162	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
In vivo	Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1].

Chemical Properties

Molecular Weight	265.66
Formula	C10H11ClF3N3
Cas No.	132834-56-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (846.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7642 mL	18.8210 mL	37.6421 mL	188.2105 mL
5 mM	0.7528 mL	3.7642 mL	7.5284 mL	37.6421 mL
10 mM	0.3764 mL	1.8821 mL	3.7642 mL	18.8210 mL
20 mM	0.1882 mL	0.9411 mL	1.8821 mL	9.4105 mL
50 mM	0.0753 mL	0.3764 mL	0.7528 mL	3.7642 mL
100 mM	0.0376 mL	0.1882 mL	0.3764 mL	1.8821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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