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Org-12962
🥰Excellent
Catalog No. T16401Cas No. 132834-56-1
Org-12962 is an effective and selective 5-HT2CÂ receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2AÂ and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
Org-12962
🥰Excellent
Purity: 98.34%
Catalog No. T16401Cas No. 132834-56-1
Org-12962 is an effective and selective 5-HT2CÂ receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2AÂ and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $56 | In Stock | |
| 25 mg | $83 | In Stock | |
| 50 mg | $113 | In Stock | |
| 100 mg | $162 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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Purity:98.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Org-12962 is an effective and selective 5-HT2CÂ receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2AÂ and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively). |
| Targets&IC50 | 5-HT2C receptor:7.01 （pEC50）, 5-HT2A receptor:6.38 （pEC50）, 5-HT2B receptor:6.28 （pEC50） |
| In vivo | Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1]. |
| Molecular Weight | 265.66 |
| Formula | C10H11ClF3N3 |
| Cas No. | 132834-56-1 |
| Smiles | FC(F)(F)C1=CC=C(N=C1Cl)N1CCNCC1 |
| Relative Density. | 1.352 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225 mg/mL (846.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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